Apoptosis Lymphoid, Epithelial, and Neuronal Cell Lines from Death by Human Immunodeficiency Virus Type 1 Tat Protein Protects
نویسندگان
چکیده
We report here that the tat gene product of human immunodeficiency virus type 1 was able to protect iymphoblastoid (Jurkat), epithelial (293) and neuronal (PC12) cell lines from apoptotic death induced by serum withdrawal. The rescue from apoptosis by Tat was reflected by an increased expression of Bci-2 protein in tat-positive Jurkat cells with respect to mock-transfected Jurkat cells after 3-6 days of serum-free cultures. We propose that the ability of the regulatory human immunodeficiency virus type 1 Tat protein to suppress apoptosis might have important implications in understanding the pathogenesis of frequent neoplastic disorders observed in human immunodeficiency virus type 1-seropositive individuals.
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